Effects of Aging on the Expressions of Insulin Receptor Substrate-1, Phosphate Protein Kinase B in Rat Liver and Muscle 老龄大鼠肝脏和骨骼肌胰岛素受体底物-1及磷酸化蛋白激酶B的表达
Construction of cell model based on reporter gene for identifying agonist of insulin receptor protein-tyrosine kinase 基于报告基因的胰岛素受体蛋白酪氨酸激酶激动剂细胞筛选模型的建立
The post receptor signal transduction consists of a series of receptor associated tyrosine protein kinase activated intracellular protein phosphorylation and dephosphorylation reactions, such as the phosphorylation of insulin receptor substrate 1 ( IRS 1), Shc, Ras and phosphatidylinositol 3 kinase ( PI3 K). 受体后的信号转导经过了一系列磷酸化和去磷酸化等途径,其中有胰岛素受体底物1(IRS1)、Shc蛋白、Ras蛋白以及磷酸肌醇3激酶(PI3K)等的参与。
The results showed that the tyrosine protein kinase activities and number of insulin receptors in differentiated, cells were reduced. An endogenous substrate for tyrosine protein kinase disappeared in differentiated cells. 结果表明,诱导分化后的细胞酪氨酸蛋白激活酶活性降低,胰岛素受体数量减少,酪氨酸蛋白激酶的一底物蛋白在分化后消失。
Objective To investigate the change of insulin receptor tyrosine kinase ( TK) activity in the pathogenesis of insulin resistance ( IR). 目的探讨胰岛素受体酪氨酸激酶(TK)活性变化在胰岛素抵抗(IR)发生中的作用。
Effects of exercise and insulin on c-Jun NH_2-terminal kinase activity and p38 phosphorylation in skeletal muscle of rats with hyperglycemia 运动和胰岛素对高血糖大鼠骨骼肌JNK和p38信号传导系统的调节作用
Methods: To observe the changes in plasma glucose level, plasma insulin level, insulin receptor ( IR) binding property and its tyrosine protein kinase ( IR TPK) activity. After the rats with 30% TBSA full thickness skin burns were fed with vanadate. 方法:用钒酸钠胃饲30%TB-SAⅢ度烫伤大鼠,观察血糖、胰岛素、肌细胞膜胰岛素受体结合特性和胰岛素受体酪氨酸蛋白激酶(IR-TPK)活性的改变。
Insulin receptor substrate-1 ( IRS-1) acts as a multisite docking protein that binds signal proteins and links the receptor kinase to a number of cellular functions that are regulated by insulin. 胰岛素受体底物-1(Insulinreceptorsubstrate-1,IRS-1)作为多位点的锚定蛋白,连接受体激酶和信号蛋白质,引起受胰岛素调节的许多细胞内的多种功能的活化。
Insulin receptor tyrosine kinase activity and substrate 1 ( IRS-1) expression in human myometrium and leiomyoma 人体子宫肌层和平滑肌瘤组织中胰岛素受体酪氨酸激酶活性与底物1(IRS-1)的表达
The activity of glycogen synthase kinase 3 β( GSK-3 β), a key component of insulin signal transduction pathway and a known tau kinase, in the hippocampus of rats was determined by using γ-32P-ATP and the specific peptide substrate. γ-32P-ATP和特异性底物肽检测海马内胰岛素信号传导系统中的关键酶糖原合成酶激酶-3β(Glycogensynthasekinase-3β,GSK-3β)活性。
Effect of thiazolidinedione on insulin receptor kinase in diabetic patients 胰岛素增敏剂对糖尿病患者胰岛素受体激酶的影响
Amelioration of insulin resistance after scald by c-Jun N-terminal kinase inhibitor in rat c-Jun氨基末端激酶抑制剂减轻烫伤后胰岛素抵抗的实验研究
Purification of insulin receptor and characterization of its protein kinase 胰岛素受体的分离纯化及其酪氨酸蛋白激酶特性的研究
Effects of insulin on the distribution of actins in vascular smooth muscle cells in the process of proliferation via mitogen-activated protein kinase in vitro 胰岛素影响自发性高血压大鼠血管平滑肌细胞增殖及肌动蛋白分布的丝裂原激酶的机制探讨
Both IL-6 and TNF-a treatments for 72 h inhibited insulin-stimulated glucose uptake, tyrosine phosphorylations of insulin receptor substrate-1 ( IRS-1) and protein kinase B ( PKB) phosphorylation, and IRS-1 expression. 两者作用72h抑制胰岛素刺激的葡萄糖摄取、胰岛素受体底物1(IRS-1)酪氨酸及蛋白激酶B(PKB)磷酸化,并使IRS-1表达下降。
Effect of different free fatty acids on hepatic insulin resistance and protein kinase C-delta 不同脂肪酸对肝脏胰岛素抵抗和蛋白激酶C-δ活性的影响
Binding of Insulin Receptor Substrate 1 PH Domain to Protein Kinase C 胰岛素受体底物1的PH结构域与PKC的结合
The effect of insulin on the expression of protein kinase C in diabetic rat glomerulus 胰岛素对糖尿病大鼠肾小球蛋白激酶C表达的调控
The Measurement of Insulin Receptor Tyrosine Kinase Activity from Human Erythrocytes 人红细胞胰岛素受体酪氨酸蛋白激酶活性的测定
The [ Ca2+] I of circulating mononuclear cells in type 2 diabetes mellites patients was positively correlated with FBG, FINS, and negatively with the insulin receptor tyrosine kinase activity. 相关分析显示型糖尿病患者单个核细胞内2Ca2+浓度与、显著正相关,与受体活性显著负相关。
Objective: To establish a method of detecting insulin receptor tyrosine kinase ( IRTK) activity from erythrocytes. 目的:建立红细胞胰岛素受体酪氨酸蛋白激酶(IRTK)的活性测定法。
Methods: The [ Ca2+] I was assayed with fluorescence spectroscopic analysis and the insulin receptor tyrosine kinase activity was assayed with enzyme-linked immunosorbent assay method in circulating mononuclear cells in 40 type 2 diabetes mellites patients and 20 normal subjects. TPK方法:荧光分光分析法测定例型糖尿病及例正常对照单个核细胞内40220Ca2+浓度,并用酶联免疫法测定单个核细胞胰岛素受体酪氨酸激酶()活性。
No significant changes in activity of insulin receptor tyrosine protein kinase and its sensitivity to insulin stimulation in the skeletal muscle were observed. 手术前后骨骼肌细胞膜胰岛素受体TPK活性以及对胰岛素刺激的反应性均无明显改变。
Objective To investigate the relationship between the expression of insulin receptor ( IR) and the content of tyrosine protein kinase ( TPK) in patients with hepatic cirrhosis. 目的探索肝硬化时肝组织细胞胰岛素受体(IR)和酪氨酸蛋白激酶(TPK)含量的变化规律。
The specificity of cell model was tested by the Tyrphostin of insulin receptor kinase. 通过IR激酶抑制剂考察细胞模型的特异性。
AIM: To study the effect of insulin sensitivity agonist& rosiglitazone on protein kinase B ( PKB) expression of insulin resistant rats skeletal muscle. METHODS: Insulin resistant rat model was induced by high fat diet feeding. 目的:探讨胰岛素增敏剂罗格列酮对胰岛素抵抗大鼠骨骼肌蛋白激酶B(PKB)表达的影响。